Key result
At least 10 fibroblasts with capacitance 4.5 pF had to be connected to each myocyte with capacitance 153.4 pF to slow down the conduction by >10%.
Population
One-dimensional biophysical model of a strand of myocytes covered by a layer of fibroblasts
Comparison
Varying fibroblast densities and… vs Baseline/uncoupled state or varying levels of…
Design
Preclinical
Authors
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Significant coupling needed to slow conduction; leaves open whether decoupling primarily drives slowing in human fibrotic hearts.
Computational modeling demonstrates that significant myocyte-fibroblast coupling is required to slow conduction, suggesting microstructural changes and myocyte decoupling are the primary drivers of slow conduction in fibrotic tissue.
Jacquemet et al. (2007) studied Myocyte-fibroblast coupling. Myocyte-fibroblast coupling and fibroblast density vs. Different coupling strengths and densities was evaluated on Conduction and maximal upstroke velocities. At least 10 fibroblasts with capacitance 4.5 pF had to be connected to each myocyte with capacitance 153.4 pF to slow down the conduction by >10%.
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