Population
Isolated pairs of ventricular cells from adult rat and guinea pig hearts
Comparison
Whole-cell, tight-seal recording using patch… vs Two single myocytes gently pushed together
Design
Preclinical
Authors
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Thresholds refine biophysical models of ventricular coupling; leaves open validation in human myocardium.
Action potential transfer between ventricular myocytes depends on nexal membrane resistance, requiring an estimated minimum of more than 13 connexons to allow impulse transfer.
Weingart et al. (1988) studied this question.
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