Key result
Higher apical-septal calibrated integrated backscatter linked to ventricular arrhythmias.
Why the study?
Ventricular scars provide a substrate for ventricular arrhythmias, but CMR quantification has limitations in patients with ICDs.
Is calibrated integrated backscatter (cIBS) measured by echocardiography associated with arrhythmia frequency in patients with ischemic dilated cardiomyopathy and an ICD?
Observational (n=32)
Is calibrated integrated backscatter (cIBS) measured by echocardiography associated with arrhythmia frequency in patients with ischemic dilated cardiomyopathy and an ICD?
Calibrated integrated backscatter (cIBS) measured by echocardiography is associated with higher ventricular arrhythmia frequency in patients with ischemic dilated cardiomyopathy, potentially offering an alternative to CMR for scar assessment.
Should not yet alter ICD risk stratification in ischemic cardiomyopathy; leaves open cIBS validation versus CMR for scar assessment.
BACKGROUND: Ventricular scars due to myocardial infarction provide a substrate for ventricular arrhythmias, and cardiac magnetic resonance (CMR) is the golden standard for the quantification of scar tissue magnitude. CMR has still limitations with patients with ICD despite ICD's becoming MR-compatible. We investigated the association between calibrated integrated backscatter (cIBS) and arrhythmia frequency in patients with ICD. METHODS: Thirty-two ischemic dilated cardiomyopathy (ICM) patients with VVI-ICD (mean age 66.56 ± 9.05, 28 male, and four female) were divided into three groups according to their arrhythmia frequency (ventricular arrhythmia-[VA -], VA + [VA +], and arrhythmia storm [AS]). Then with transthoracic echocardiography (TTE), all patients' cIBS values were calculated and these values were compared with the patients' arrhythmia frequency. RESULTS: cIBS values of patients with VA + and AS were significantly higher in the apical-septal (0.66 ± 0.11 vs. 0.50 ± 0.16, p = .008) and apical-lateral (0.62 ± 0.19 vs. 0.46 ± 0.18, p = .041) segments compared to those of patients with VA -. The cIBS values of apical-septal (0.50 ± 0.16 vs. 0.65 ± 0.08 vs. 0.66 ± 0.13 respectively, p = .032) and apical-anterior (0.53 ± 0.22 vs. 0.48 ± 0.17 vs. 0.79 ± 0.23 respectively, p = .03) segments were significantly different between the groups. Furthermore, in the post hoc analysis, the difference was significantly higher in VA + than VA - in the apical-septal segment and higher in AS than VA + in apical-anterior segments. CONCLUSION: Our findings suggest an association between the cIBS values and arrhythmia frequency in the study group.
No takes yet. Share an insight, caveat, or question.
Karaayvaz et al. (2021) conducted an observational in Ischemic dilated cardiomyopathy (n=32). Calibrated integrated backscatter (cIBS) vs. Patients without ventricular arrhythmia (VA-) was evaluated on cIBS values in the apical-septal segment (p=0.008). Calibrated integrated backscatter values in the apical-septal segment were significantly higher in patients with ventricular arrhythmias compared to those without (0.66 vs 0.50, p=0.008).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: