Key result
Male gender is linked to ~118% higher long-term mortality after triple heart valve surgery.
Why the study?
Female gender is a risk factor in several cardiac surgery risk stratification systems, prompting investigation into outcome differences between men and women following triple heart valve surgery.
Does female gender affect survival and postoperative outcomes in patients undergoing triple heart valve surgery?
Cohort (n=250)
Does female gender affect survival and postoperative outcomes in patients undergoing triple heart valve surgery?
Contrary to traditional cardiac surgery risk scores, female gender is associated with better long-term survival following triple heart valve surgery.
Males may face higher long-term mortality after triple valve surgery; challenges traditional risk scores and leaves open need for gender-specific validation.
Female gender is a risk factor in several cardiac surgery risk stratification systems. This study explored the differences in the outcomes following triple heart valve surgery in men vs women. The study included 250 patients (males n = 101; females n = 149) who underwent triple valve surgery from 2009 to 2020. BMI (body mass index) was higher in females (29.6 vs 26.5 kg/m 2 , P < .001), and diabetes was more common in males (44 vs 42%, P = .012). The ejection fraction was higher in females (55 vs 50%, P < .001). The severity of mitral valve stenosis and tricuspid valve regurgitation was significantly greater in females (33.11 vs 27.72%, P = .003 and 44.30 vs 19.8%, P < .001, respectively). Mitral valve replacement was more common in females ( P < .001), and they had lower concomitant coronary artery bypass grafting ( P = .001). Bleeding and renal failure were lower in females ( P = .021 and <0.001, respectively). Hospital mortality, readmission, and reintervention were not significantly different between genders. By multivariable analysis, male gender was a risk factor for lower survival [HR (hazard ratio): 2.18; P = .024]. Triple valve surgery can be performed safely in both genders, with better long-term survival in females. Female gender was not a risk factor in patients undergoing triple valve surgery.
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Alhijab et al. (2024) conducted a cohort in Triple heart valve surgery (n=250). Male gender vs. Female gender was evaluated on Survival (HR 2.18, p=0.024). Male gender was a significant risk factor for lower long-term survival following triple heart valve surgery compared to female gender (HR 2.18; P=0.024).
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