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January 10, 2023European Heart Journal - Cardiovascular ImagingOpen Access

Cardiac magnetic resonance in giant cell myocarditis: a matched comparison with cardiac sarcoidosis

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Key result

CMR findings in GCM mimic cardiac sarcoidosis despite ~30% less LGE mass.

  • P=0.037
  • n=36

Why the study?

Giant cell myocarditis is an inflammatory cardiomyopathy akin to cardiac sarcoidosis, motivating a study to examine CMR findings in giant cell myocarditis and compare them with cardiac sarcoidosis.

Does cardiac magnetic resonance imaging differentiate giant cell myocarditis from cardiac sarcoidosis?

Population

18 GCM patients and 18 matched CS controls

Comparison

Giant cell myocarditis vs cardiac sarcoidosis

Design

Matched comparative study with blinded CMR analysis

Authors

PPPauli PöyhönenUniversity of HelsinkiHNHanna‐Kaisa NordenswanUniversity of HelsinkiJLJukka LehtonenHeart Failure & Transplant

Discussion

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Overview

CMR cannot qualitatively distinguish giant cell myocarditis from sarcoidosis; leaves open whether LGE mass or acuity aids noninvasive diagnosis.

Study Design

Type

Case-Control (n=36)

Blinding

Blinded to clinical data

Structured PICO

Does cardiac magnetic resonance imaging differentiate giant cell myocarditis from cardiac sarcoidosis?

P
Population
36 patients, comprising 18 with giant cell myocarditis (GCM) and 18 with cardiac sarcoidosis (CS) matched for age, sex, left ventricular ejection fraction, and presenting cardiac manifestations.
I
Intervention
Cardiac magnetic resonance (CMR) imaging in patients with giant cell myocarditis.
C
Comparator
Cardiac magnetic resonance (CMR) imaging in matched controls with cardiac sarcoidosis.
O
Outcome
CMR imaging findings including left ventricular diastolic volume, late gadolinium enhancement (LGE) distribution, and LGE mass.surrogate

Main Result

Absolute Event Rate: 17.4% vs 25%

p-value: p=0.037

CMR findings in giant cell myocarditis are qualitatively indistinguishable from cardiac sarcoidosis, though GCM presents with smaller LV size and LGE mass despite more acute clinical inflammation.

Cite This Study

Pöyhönen et al. (2023) conducted a case-control in Giant cell myocarditis (n=36). Cardiac magnetic resonance (CMR) imaging vs. Cardiac sarcoidosis (CS) was evaluated on Late gadolinium enhancement (LGE) mass (% of LV mass) (p=0.037). Cardiac magnetic resonance findings in giant cell myocarditis are qualitatively indistinguishable from cardiac sarcoidosis, though LGE mass is smaller in GCM (17.4% vs 25.0%, P=0.037).

synapsesocial.com/papers/6a15979c79ff98d0de4edb66https://doi.org/10.1093/ehjci/jeac265
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Phenotyping of giant cell myocarditis versus cardiac sarcoidosis using cardiovascular magnetic resonance2023 · 15 citations
  2. 2Two bad actors: can cardiac magnetic resonance distinguish idiopathic granulomatous from giant cell myocarditis?2023
  3. 3Manifestations and Outcome of Cardiac Sarcoidosis and Idiopathic Giant Cell Myocarditis by 25‐Year Nationwide Cohorts2021 · 60 citations
  4. 4Cardiovascular magnetic resonance imaging and endomyocardial biopsy in giant cell myocarditis: a case report on diagnostic challenges and future perspectives2025 · 2 citations
  5. 5Diagnosis, management, and outcome of cardiac sarcoidosis and giant cell myocarditis: a Swedish single center experience2022 · 29 citations