Key result
Angiotensin II receptor blockers (ARBs), unlike ACE inhibitors, reduce the risk of cardiovascular disease outcomes, particularly stroke, and Type 2 diabetes in patients with hypertension.
Why the study?
Do ARBs reduce cardiovascular outcomes and Type 2 diabetes risk better than ACE inhibitors in patients with hypertension?
Do ARBs reduce cardiovascular outcomes and Type 2 diabetes risk better than ACE inhibitors in patients with hypertension?
ARBs may provide superior reduction in cardiovascular outcomes, particularly stroke, compared to ACE inhibitors in hypertensive patients.
ARBs may reduce stroke and diabetes risk more than ACE inhibitors in hypertension; challenges perceived equivalence but leaves direct comparison open.
Agents that counteract the negative impact of the renin-angiotensin-aldosterone system (RAAS) are effective antihypertensives and reduce the risk of developing Type 2 diabetes. Contrary to common perception, angiotensin-converting enzyme inhibitors do not share the apparent benefit of angiotensin II receptor blockers (ARBs) in reducing risk of cardiovascular-disease outcomes, particularly stroke, in randomised clinical trials. RAAS agents, especially ARBs, are well tolerated. Use of ARBs alone or in combination with other classes of antihypertensive agents to lower blood pressure and/or medications to control other conditions (e.g., insulin sensitivity) reduces risk of cardiovascular disease outcomes and Type 2 diabetes with excellent tolerability. Selected issues related to use of RAAS agents as antihypertensive therapies (e.g., Type 2 diabetes, global risk management, multiple drug therapy and coronary heart disease) are addressed.
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Kjeldsen et al. (2005) conducted a review in Hypertension. Angiotensin receptor blockers (ARBs) and ACE inhibitors was evaluated on Cardiovascular disease outcomes and Type 2 diabetes. Angiotensin II receptor blockers (ARBs), unlike ACE inhibitors, reduce the risk of cardiovascular disease outcomes, particularly stroke, and Type 2 diabetes in patients with hypertension.
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