Variability of echocardiographic measures of left ventricular diastolic function. The HUNT study
Key result
Image acquisition drives ~24% of LV diastolic variance, but 3D LAV max improves agreement over 2D.
- n=40
Why the study?
The study was conducted to investigate variability related to image acquisition and reading for echocardiographic measures of LV diastolic function, and its impact on classifying LVDD.
What is the variability related to image acquisition and reading process for echocardiographic measures of left ventricular diastolic function?
Population
Forty participants (19 women) mean age 62 (28–88) years
Comparison
Repeated echocardiography by different echocardiographers and blinded analysis by four readers
Design
Blinded cross-sectional reproducibility study
Authors
Discussion
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Implication
Acquisition variability dominates LV diastolic measures; supports protocol standardization and further 3D validation studies.
Key Points
- This research aimed to investigate the variability in echocardiographic measures of left ventricular diastolic function and its impact on classification of diastolic dysfunction.
- Forty participants underwent echocardiographic examinations twice by different echocardiographers.
- Four blinded readers analyzed the images in a cross-sectional design.
- Variability was assessed using variance component analyses and Kappa statistics.
- Image acquisition influenced variability more than image reading (mean 24% vs. 4% of variance).
- 2D LAV max showed 16% variability, while 3D LAV max showed only 4%.
- Kappa for classification of LVDD was 0.42, improving to 0.58 with 3D LAV max.
Study Design
Type
Cross-Sectional (n=40)
Blinding
Blinded
Structured PICO
What is the variability related to image acquisition and reading process for echocardiographic measures of left ventricular diastolic function?
P
Population
40 participants, mean age 62 (range 28-88) years, 19 women
I
Intervention
Echocardiographic examinations twice by different echocardiographers and blinded analyses by four readers (including 2D and 3D LAV max, spectral Doppler, and tissue velocities)
O
Outcome
Variability and reproducibility measures of echocardiographic measures of left ventricular diastolic functionsurrogate
Image acquisition contributes more to variability in echocardiographic assessment of LV diastolic function than image reading, and 3D left atrial volume measurement improves classification reliability compared to 2D.
Cite This Study
Letnes et al. (2021) conducted a cross-sectional in Left ventricular diastolic dysfunction (n=40). Image acquisition and reading process (2D vs 3D LAV max) was evaluated on Variability related to image acquisition and reading process for echocardiographic measures of LV diastolic function. Image acquisition influenced variability of LV diastolic function measures more than reading (24% vs 4% of variance), while 3D LAV max improved classification agreement over 2D (Kappa 0.58 vs 0.42).