Key result
Living Heart simulations show stroke volume and SBP peak at a 120 ms AV delay.
Why the study?
Whole-heart computational models help evaluate medical devices when bench-top and animal tests fall short, but existing models were calibrated only for resting heart rates of 60 beat/min.
Population
Dassault Systèmes Living Heart Human Model of whole-human-heart electromechanics
Comparison
Heart rates from 90−160 beat/min vs resting state at 60 beat/min
Design
Finite-element computational modeling study
Authors
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Model recalibration enables virtual AV optimization at high rates; leaves open clinical translation pending prospective validation.
The Living Heart Human Model can be computationally recalibrated to simulate elevated heart rates, providing a virtual platform to evaluate pacing hemodynamics and AV delay optimization.
Jiang et al. (2022) studied Healthy heart simulation. Living Heart Human Model (LHHM) recalibration vs. Resting state (60 bpm) was evaluated on Physiological responses at heart rates ranging from 90-160 bpm. Adjusting six parameters in the Living Heart Human Model enabled simulation of heart rates from 90-160 bpm, showing stroke volume and systolic blood pressure peaked at an AV delay of 120 ms at 90 bpm.