Why the study?
Does heart rate control by atrial pacing alter cardiovascular dynamics in normal patients at rest and during exercise?
Population
n=10 normal patients
Comparison
Heart rate control by atrial pacing at rest and… vs Each patient served as his own control
Authors
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Supports rate-independent cardiac output in normals; leaves open whether dynamics apply in cardiovascular disease.
Does heart rate control by atrial pacing alter cardiovascular dynamics in normal patients at rest and during exercise?
In normal patients, changes in heart rate via atrial pacing do not significantly alter cardiac index, left ventricular work, or peripheral resistance, but do decrease stroke index and mean systolic ejection rate linearly.
Stein et al. (1966) studied this question.
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