What is the clinical evidence from this study?

Study design: Cross-Sectional. Population: Major depressive disorder with inadequate response to antidepressant treatments (n=2096). Intervention: Antidepressant treatments (ADT). Primary outcome: Frequency of frustration regarding medication.

February 5, 2018BMC PsychiatryOpen Access

Understanding the emotions of patients with inadequate response to antidepressant treatments: results of an international online survey in patients with major depressive disorder

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Key result

Among patients with major depressive disorder and inadequate response to antidepressants, 29.8% reported feeling frustrated with their medication, which was associated with a desire to quit medication in 33.3% of frustrated patients.

Population

2096 adults diagnosed with major depressive disorder by a healthcare professional, experiencing symptoms of…

Design

Cross-sectional

Authors

RMRajnish MagoSUNY Upstate Medical University AFAndrea FagioliniUniversity of Siena EWEmmanuelle WeillerOtsuka (Japan)

Discussion

Member takes

Implication

Medication frustration may signal adherence risk in inadequately responding MDD; leaves open whether addressing it improves persistence.

Study Design

Type

Cross-Sectional (n=2,096)

Multicenter

Yes

Structured PICO

Population

2096 adults (age 18-65) diagnosed with major depressive disorder (MDD) by a healthcare professional, experiencing symptoms of depression most of the time over the past week with moderate to extreme impact on overall functioning, currently on an antidepressant treatment for at least 6 weeks at an adequate dose, and experiencing an inadequate response. Mean age 42.1 years, 56.7% female. Multinational (6 countries: US, Canada, UK, Germany, France, Spain).

Intervention

Antidepressant treatments (ADTs) for at least 6 weeks at an adequate dose

Outcome

Patient perspectives on the emotional impact of experiencing an inadequate response to ADTs, specifically feelings of frustration with medications and health care provider (HCP)patient reported

In patients with major depressive disorder experiencing inadequate response to antidepressants, feelings of frustration are common and can negatively impact treatment adherence and the patient-provider relationship.

Limitations

Did not explore the influence of culture or differing healthcare systems on the feelings of frustration
Conducted only in Western countries, limiting generalizability to other regions
Relied on patient self-report surveys without comparison to objective clinical information
Used subjective scales instead of standard clinical scales to define inadequate response
Recruitment from existing consumer panels may have introduced selection bias
Conducted in Western countries, limiting generalizability to other regions
Based on patient self-report without objective clinical information comparison
Recruited from existing consumer panels which may introduce bias

Cite This Study

Mago et al. (2018) conducted a cross-sectional in Major depressive disorder with inadequate response to antidepressant treatments (n=2,096). Antidepressant treatments (ADT) was evaluated on Frequency of frustration regarding medication. Among patients with major depressive disorder and inadequate response to antidepressants, 29.8% reported feeling frustrated with their medication, which was associated with a desire to quit medication in 33.3% of frustrated patients.

synapsesocial.com/papers/6a15a321cb0379474a8266c8 https://doi.org/10.1186/s12888-018-1625-y

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Understanding the emotions of patients with inadequate response to antidepressant treatments: results of an international online survey in patients with major depressive disorder

Discussion

Member takes

Implication

Study Design

Structured PICO

Limitations

Cite This Study

Understanding the emotions of patients with inadequate response to antidepressant treatments: results of an international online survey in patients with major depressive disorder

Discussion

Member takes

Implication

Study Design

Structured PICO

Limitations

Cite This Study

Also Consider

Also Consider