What question did this study set out to answer?

To outline rational design principles and key structural motifs that guide the development of safe and potent next-generation ionizable lipids for nucleic acid delivery.

September 2, 2025Molecular Therapy — Methods & Clinical DevelopmentOpen Access

Design of cationic ionizable lipids for the delivery of therapeutic nucleic acids

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Authors

NAN. D. Prasad Atmuri FSFariba SaadatiFPInnovations JKJayesh A. KulkarniFPInnovations

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Implication

Review reveals design principles of next-generation ionizable lipids in nanoparticle delivery, highlighting structural features that enhance nucleic acid potency and safety.

Key Points

To outline rational design principles and key structural motifs that guide the development of safe and potent next-generation ionizable lipids for nucleic acid delivery.
Synthesized evidence on chemical design principles, structural motifs, and performance parameters of ionizable cationic lipids in lipid nanoparticle formulations.
Evaluated lipid architectures contributing to encapsulation efficiency, biological tolerability, and endosomal escape alongside unconventional design strategies.
Identified distinct structural motifs within ionizable lipids that improve nucleic acid delivery potency, tolerability, and endosomal escape.
Demonstrated that chemical architectures deviating from conventional heuristic guidelines broaden the usable chemical space for future genetic medicines.

Cite This Study

Atmuri et al. (2025) studied this question.

synapsesocial.com/papers/6a15ac5cd64fa333899ff07e https://doi.org/10.1016/j.omtm.2025.101585

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Implication

Review reveals design principles of next-generation ionizable lipids in nanoparticle delivery, highlighting structural features that enhance nucleic acid potency and safety.

Design of cationic ionizable lipids for the delivery of therapeutic nucleic acids

Discussion

Member takes

Implication

Key Points

Cite This Study

Design of cationic ionizable lipids for the delivery of therapeutic nucleic acids

Discussion

Member takes

Implication

Key Points

Cite This Study

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