Key result
A calculated insulin sensitivity index (ISI-cal) incorporating fasting insulin, triglycerides, and waist-to-hip ratio predicted incident cardiovascular disease significantly better than HOMA-IR (AUC 0.74 vs 0.61).
Why the study?
Does a calculated insulin sensitivity index (ISI-cal) improve prediction of incident cardiovascular disease and diabetes compared to HOMA-IR in healthy adults?
Cohort (n=4,003)
Does a calculated insulin sensitivity index (ISI-cal) improve prediction of incident cardiovascular disease and diabetes compared to HOMA-IR in healthy adults?
Absolute Event Rate: 0.74% vs 0.61%
p-value: p=<0.001
A novel insulin sensitivity index combining fasting insulin, triglycerides, and waist-to-hip ratio outperforms HOMA-IR in predicting incident cardiovascular disease.
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May aid CVD risk prediction beyond HOMA-IR; leaves open whether adoption improves outcomes or warrants practice change.
Venkataraman et al. (2013) conducted a cohort in Cardiometabolic risk (n=4,003). Calculated Insulin Sensitivity Index (ISI-cal) vs. HOMA-IR was evaluated on Incident cardiovascular disease (ROC AUC) (p=<0.001). A calculated insulin sensitivity index (ISI-cal) incorporating fasting insulin, triglycerides, and waist-to-hip ratio predicted incident cardiovascular disease significantly better than HOMA-IR (AUC 0.74 vs 0.61).
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