Key result
Multiple risk factors drive AF pathogenesis via triggers, drivers, and abnormal substrates.
Why the study?
The incidence of AF is rising, but its exact mechanisms and pathogenesis remain poorly understood despite significant implications for clinical management.
Provides a comprehensive overview of the etiology, pathology, and classification of atrial fibrillation.
Answers are grounded in this paper and cite their sources.
Consolidates AF etiology knowledge for clinical risk assessment; leaves open targeted mechanistic trials.
Atrial fibrillation (AF) is a disorganized tachyarrhythmia with significant public health importance due to high morbidity, mortality, and health-care costs. Incidence rate of AF is on the rise and there are several modifiable and nonmodifiable risk factors that are responsible. Exact mechanisms and pathogenesis of AF are still poorly understood, yet they still have great implications in management. The aim of this article is to summarize the epidemiology, major risk factors, and their role in the pathogenesis of AF. Finally, we have reviewed the classification of AF as per professional society guidelines.
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Nayak et al. (2020) conducted a review in Atrial Fibrillation. Atrial fibrillation is a complex tachyarrhythmia driven by multiple modifiable and nonmodifiable risk factors, with pathogenesis involving triggers, drivers, and abnormal substrates.
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