Key result
Paroxetine significantly reduced recurrent suicidal behavior compared to placebo among patients with fewer than five previous suicide attempts (17% vs 36%).
Why the study?
Does paroxetine reduce recurrent suicidal behavior in patients with repeated suicide attempts but not major depression?
RCT (n=91)
Double-blind
Does paroxetine reduce recurrent suicidal behavior in patients with repeated suicide attempts but not major depression?
Absolute Event Rate: 17% vs 36%
Paroxetine may reduce recurrent suicidal behavior in patients with a history of multiple suicide attempts who do not have major depression.
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Supports paroxetine for reducing recurrent suicidal behavior in nondepressed patients with <5 prior attempts; extends SSRI evidence to suicide prevention outside depression.
Verkes et al. (1998) conducted an RCT in Repeated suicide attempts without major depression (n=91). Paroxetine vs. Placebo was evaluated on Recurrent suicidal behavior. Paroxetine significantly reduced recurrent suicidal behavior compared to placebo among patients with fewer than five previous suicide attempts (17% vs 36%).
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