Key result
The cardiac thin filament is actively involved in beat-to-beat control of cardiac function by neural and hormonal factors and the Frank-Starling mechanism.
Design
Review
Authors
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May inform contractility modulation in heart failure; leaves open prospective clinical validation.
Highlights the active role of cardiac thin filaments in regulating contractility and relaxation beyond simple calcium responsiveness.
Kobayashi et al. (2004) conducted a review in Cardiac contractility. The cardiac thin filament is actively involved in beat-to-beat control of cardiac function by neural and hormonal factors and the Frank-Starling mechanism.
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