Key result
Intramyocardial theranostic hydrogel reduces Tei index ~8% and stabilizes LV hemodynamics in a post-MI porcine model.
Why the study?
Does intramyocardial delivery of a therapeutic hydrogel improve LV hemodynamics and function in a porcine model early post-MI?
Does intramyocardial delivery of a therapeutic hydrogel improve LV hemodynamics and function in a porcine model early post-MI?
Absolute Event Rate: 0.46% vs 0.5%
p-value: p=0.0004
Intramyocardial injection of a theranostic hydrogel early post-MI in a porcine model acutely stabilizes LV hemodynamics and improves LV function as evaluated by contrast cineCT.
Hypothesis-generating in porcine post-MI model; leaves open translation to human therapy.
Our study demonstrates that contrast cineCT imaging can be used to evaluate the acute effects of intramyocardial delivery of a therapeutic hydrogel to the central MI region early post MI, which resulted in a rapid stabilization of LV hemodynamics and improvement in regional and global LV function.
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Avendaño et al. (2023) studied Myocardial Infarction (n=13). Intramyocardial injection of a theranostic hydrogel vs. No hydrogel delivery was evaluated on Tei index (myocardial performance index) (p=0.0004). Intramyocardial delivery of a theranostic hydrogel early post-myocardial infarction in a porcine model rapidly stabilized LV hemodynamics and improved regional LV function, significantly reducing the Tei index.
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