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January 18, 2016Journal of Cardiovascular ElectrophysiologyOpen Access

Noninvasive Estimation of Epicardial Dominant High‐Frequency Regions During Atrial Fibrillation

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Key result

Noninvasive estimation of atrial dominant frequency maps via the inverse problem of electrocardiography achieved an 8.8 ± 4.4% relative error, providing higher accuracy than temporal patterns.

Why the study?

Does noninvasive estimation using the inverse problem of electrocardiography accurately reconstruct dominant frequency maps compared to intracardiac electrograms in patients with atrial fibrillation?

Population

n=4 representative atrial fibrillation patients with left-to-right and right-to-left atrial dominant…

Comparison

Noninvasive estimation of dominant frequency and… vs Simultaneous intracardiac electrograms from both…

Design

Other

Authors

JPJorge Pedrón-TorrecillaUniversitat Politècnica de ValènciaMRMiguel RodrigoUniversitat de ValènciaACAndreu M. ClimentAdif (Spain)

Discussion

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Implication

Hypothesis-generating for noninvasive DF mapping in AF; requires prospective validation before clinical adoption.

Study Design

Type

Observational (n=4)

Structured PICO

Does noninvasive estimation using the inverse problem of electrocardiography accurately reconstruct dominant frequency maps compared to intracardiac electrograms in patients with atrial fibrillation?

P
Population
n=4 representative atrial fibrillation (AF) patients with left-to-right and right-to-left atrial dominant frequency (DF) patterns, and realistic mathematical models of atria and torso anatomy.
I
Intervention
Noninvasive estimation of dominant frequency and electrical patterns by solving the inverse problem of electrocardiography using 67-lead body surface recordings.
C
Comparator
Simultaneous intracardiac electrograms from both atria.
O
Outcome
Relative errors in voltage, phase, and frequency spectrum between inverse-computed electrograms and intracardiac electrograms.surrogate

Main Result

p-value: p=<0.01

Noninvasive reconstruction of atrial frequency maps using the inverse problem of electrocardiography provides accurate estimation of dominant frequency, outperforming temporal distribution pattern reconstruction.

Cite This Study

Pedrón-Torrecilla et al. (2016) conducted an observational in Atrial fibrillation (n=4). Noninvasive estimation of dominant frequency by solving the inverse problem of electrocardiography vs. Intracardiac electrograms was evaluated on Relative errors in voltage, phase, and frequency spectrum compared to intracardiac electrograms (p=<0.01). Noninvasive estimation of atrial dominant frequency maps via the inverse problem of electrocardiography achieved an 8.8 ± 4.4% relative error, providing higher accuracy than temporal patterns.

synapsesocial.com/papers/6a15bb89b03a896dfa823ed0https://doi.org/10.1111/jce.12931

Topics

Atrial fibrillationPersistent AF managementAF ablation outcomesAnticoagulation in AF
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Catheter Ablation of Paroxysmal Atrial Fibrillation Initiated by Non–Pulmonary Vein Ectopy2003 · 758 citations
  2. 2Noninvasive Localization of Maximal Frequency Sites of Atrial Fibrillation by Body Surface Potential Mapping2013 · 136 citations
  3. 3Manifestation of Left Atrial Events and Interatrial Frequency Gradients in the Surface Electrocardiogram During Atrial Fibrillation: Contributions from Posterior Leads2009 · 34 citations
  4. 4Spatially Distributed Dominant Excitation Frequencies Reveal Hidden Organization in Atrial Fibrillation in the Langendorff‐Perfused Sheep Heart2000 · 182 citations
  5. 5Presence of Left-to-Right Atrial Frequency Gradient in Paroxysmal but Not Persistent Atrial Fibrillation in Humans2004 · 316 citations