Why the study?
Do intensive chemotherapy regimens improve response rate and survival compared to a moderate regimen in patients with metastatic breast cancer?
Population
141 patients with metastatic breast cancer
Comparison
Intensive chemotherapy regimens CFPMV or CA vs Moderate chemotherapy regimen CFP
Design
RCT, Prospective three-arm randomized study with crossover
Authors
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Moderate regimens suffice for metastatic breast cancer induction; confirms no response or survival benefit from intensive combinations.
Do intensive chemotherapy regimens improve response rate and survival compared to a moderate regimen in patients with metastatic breast cancer?
A moderate chemotherapy regimen is as effective as more intensive regimens for induction therapy in metastatic breast cancer, with less toxicity.
Rosner et al. (1987) studied this question.
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