Why the study?
Does the CAP regimen improve response rates compared to the FAC regimen in previously untreated metastatic breast cancer?
Population
126 previously untreated patients with metastatic breast cancer who received greater than 2 cycles of…
Comparison
CAP regimen: cyclophosphamide 200 mg/m2 i.v… vs FAC regimen: 5-FU 500 mg/m2 days 1 and 8…
Design
RCT, Prospective randomized study
Authors
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CAP improves response rates over FAC in metastatic breast cancer; leaves open a clinically meaningful survival benefit.
Does the CAP regimen improve response rates compared to the FAC regimen in previously untreated metastatic breast cancer?
The CAP regimen yields a higher overall response rate than the FAC regimen in metastatic breast cancer, but does not significantly improve remission duration or overall survival.
Kolarić et al. (1989) studied this question.
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