Why the study?
Do different Adriamycin-based combination regimens (FAC, AC, A+COMFP) yield different response rates and survival in patients with previously untreated metastatic breast cancer?
Population
497 patients with previously untreated metastatic breast cancer
Comparison
Adriamycin, cyclophosphamide, and 5-fluorouracil… vs Adriamycin and cyclophosphamide (AC)
Design
RCT, prospective randomized study
Authors
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Similar efficacy among AC, FAC, and A+COMFP in metastatic breast cancer; confirms equivalence and supports toxicity-based regimen selection.
Do different Adriamycin-based combination regimens (FAC, AC, A+COMFP) yield different response rates and survival in patients with previously untreated metastatic breast cancer?
Three Adriamycin-based combination chemotherapy regimens demonstrated similar response rates and overall survival in patients with previously untreated metastatic breast cancer, though FAC was associated with more leukopenia.
Tranum et al. (1982) studied this question.
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