Key result
Female acute ischemic stroke patients receive similar in-hospital care to men with no risk-adjusted outcome differences.
Why the study?
Previous assessments of sex differences in acute ischemic stroke were limited by specific regions or populations, narrow scope, or small sample sizes.
Are there sex differences in vascular risk factors, in-hospital management, and outcomes among patients with acute ischemic stroke?
Population
838,229 patients with acute ischemic stroke in the China Stroke Center Alliance hospitals
Comparison
Women vs men
Design
Observational cohort study
Authors
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Risk factor profiles drive residual outcome gaps despite equitable care; supports risk-adjusted equity analyses but leaves open targeted prevention trials.
Observational (n=838,229)
Yes
Are there sex differences in vascular risk factors, in-hospital management, and outcomes among patients with acute ischemic stroke?
Effect estimate: ASD 1.0%
Absolute Event Rate: 34.5% vs 34.9%
Women with acute ischemic stroke present with worse vascular risk profiles than men, which accounts for their more severe presentation and greater disability at discharge despite receiving similar guideline-directed in-hospital care.
Gu et al. (2021) conducted an observational in Acute ischemic stroke (n=838,229). Female sex vs. Male sex was evaluated on Guideline-directed management measures (all-or-null summary measure) (ASD 1.0%). Female patients with acute ischemic stroke received similar in-hospital care to men (34.5% vs 34.9%), and sex-related differences in outcomes were attenuated to null after risk adjustment.