Key result
A transcriptomic meta-analysis of 4933 normal human tissue samples identified tissue-specific co-expression modules of the extended renin-angiotensin-aldosterone system organized around core transcripts.
Population
4933 samples representing 23 different normal human tissues from 143 microarray datasets
Design
Meta-analysis
Authors
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May support tissue-selective RAAS drug development; extends co-expression mapping of the extended RAAS across human tissues.
Meta-Analysis (n=4,933)
The establishment of a transcriptomic atlas for the tissue-specific organization of the extended RAAS system across 23 human tissues provides a framework for developing more selective RAAS-targeted therapies.
Nehme et al. (2015) conducted a meta-analysis in Normal human tissues (n=4,933). A transcriptomic meta-analysis of 4933 normal human tissue samples identified tissue-specific co-expression modules of the extended renin-angiotensin-aldosterone system organized around core transcripts.
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