Key result
Telmisartan treatment reduced diet-induced increases in body weight and abdominal fat mass, and restored leptin sensitivity in obese rats, independent of blood pressure reduction.
Why the study?
Does telmisartan improve symptoms of metabolic syndrome in diet-induced obese spontaneously hypertensive rats?
Population
Spontaneously hypertensive rats with obesity established by cafeteria diet (CD) feeding for 19 weeks
Comparison
Telmisartan or telmisartan + amlodipine for 17… vs Amlodipine, vehicle (C), or chow only (C)
Design
Preclinical
Follow-up
17 weeks
Authors
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Should not change practice in metabolic syndrome; leaves open translation of anti-obesity effects to humans.
Does telmisartan improve symptoms of metabolic syndrome in diet-induced obese spontaneously hypertensive rats?
High-dose telmisartan exerts anti-obesity effects and improves metabolic parameters in a rat model of diet-induced obesity, independent of its blood pressure-lowering effects.
Müller‐Fielitz et al. (2013) studied Diet-induced obesity in spontaneously hypertensive rats. Telmisartan vs. Amlodipine, telmisartan + amlodipine, chow control, and vehicle control was evaluated on Body weight and abdominal fat mass. Telmisartan treatment reduced diet-induced increases in body weight and abdominal fat mass, and restored leptin sensitivity in obese rats, independent of blood pressure reduction.
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