Key result
The Angiotensinogen 235T-allele was significantly associated with an increased risk of essential hypertension in whites (OR 1.20; 95% CI 1.11 to 1.29; P<.0001).
Why the study?
Is the angiotensinogen gene (AGT) 235T-allele associated with essential hypertension in white patients?
Population
5,493 white patients from studies published between 1992 and 1996
Comparison
Presence of the angiotensinogen gene 235T-allele vs Absence of the AGT 235T-allele
Design
Meta-analysis
Authors
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Should not change practice; leaves open refined genetic risk models after accounting for study weaknesses.
Meta-Analysis (n=5,493)
Yes
Is the angiotensinogen gene (AGT) 235T-allele associated with essential hypertension in white patients?
Effect estimate: OR 1.20 (95% CI 1.11 to 1.29)
p-value: p=<.0001
The AGT 235T-allele is weakly but significantly associated with essential hypertension in whites, though methodological weaknesses in the underlying studies warrant cautious interpretation.
Kunz et al. (1997) conducted a meta-analysis in Essential Hypertension (n=5,493). Angiotensinogen 235T-allele was evaluated on Hypertension (OR 1.20, 95% CI 1.11 to 1.29, p=<.0001). The Angiotensinogen 235T-allele was significantly associated with an increased risk of essential hypertension in whites (OR 1.20; 95% CI 1.11 to 1.29; P<.0001).
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