Key result
The Angiotensinogen 235T-allele was significantly associated with an increased risk of essential hypertension in whites (OR 1.20; 95% CI 1.11 to 1.29; P<.0001).
Why the study?
Is the angiotensinogen gene (AGT) 235T-allele associated with essential hypertension in white patients?
Meta-Analysis (n=5,493)
Yes
Is the angiotensinogen gene (AGT) 235T-allele associated with essential hypertension in white patients?
Effect estimate: OR 1.20 (95% CI 1.11 to 1.29)
p-value: p=<.0001
The AGT 235T-allele is weakly but significantly associated with essential hypertension in whites, though methodological weaknesses in the underlying studies warrant cautious interpretation.
No takes yet. Share an insight, caveat, or question.
Should not change practice; leaves open refined genetic risk models after accounting for study weaknesses.
Kunz et al. (1997) conducted a meta-analysis in Essential Hypertension (n=5,493). Angiotensinogen 235T-allele was evaluated on Hypertension (OR 1.20, 95% CI 1.11 to 1.29, p=<.0001). The Angiotensinogen 235T-allele was significantly associated with an increased risk of essential hypertension in whites (OR 1.20; 95% CI 1.11 to 1.29; P<.0001).
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