Key result
The T174M and G-217A AGT polymorphisms were significantly associated with increased risk of essential hypertension (OR 1.19, 95% CI 1.07-1.33 and OR 1.37, 95% CI 1.17-1.59, respectively).
Why the study?
Are specific Angiotensinogen (AGT) gene polymorphisms associated with an increased risk of essential hypertension?
Population
26,818 subjects from 46 studies
Comparison
Presence of 4 Angiotensinogen polymorphisms vs Absence of these specific AGT polymorphisms
Design
Meta-analysis
Authors
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AGT variants may aid polygenic risk stratification in hypertension; confirms associations across pooled genetic studies.
Meta-Analysis (n=26,818)
Are specific Angiotensinogen (AGT) gene polymorphisms associated with an increased risk of essential hypertension?
Effect estimate: OR 1.19 (95% CI 1.07 to 1.33)
p-value: p=0.002
Specific AGT gene variants, particularly T174M and G-217A, are significantly associated with an increased risk of essential hypertension, though effects may vary by ancestry.
Pereira et al. (2008) conducted a meta-analysis in Essential Hypertension (n=26,818). AGT gene polymorphisms (T174M, A-6G, A-20C, G-217A) was evaluated on Essential hypertension (OR 1.19, 95% CI 1.07 to 1.33, p=0.002). The T174M and G-217A AGT polymorphisms were significantly associated with increased risk of essential hypertension (OR 1.19, 95% CI 1.07-1.33 and OR 1.37, 95% CI 1.17-1.59, respectively).
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