Key result
AGT gene polymorphisms A-6G (OR 1.45), A-20C (OR 1.52), and G-217A (OR 2.36) were significantly associated with an increased risk of essential hypertension in the Chinese population.
Why the study?
Are AGT gene polymorphisms (A-6G, A-20C, G-217A) associated with an increased risk of essential hypertension in the Chinese population?
Meta-Analysis
Are AGT gene polymorphisms (A-6G, A-20C, G-217A) associated with an increased risk of essential hypertension in the Chinese population?
Odds Ratio: 1.45 (95% CI 1.17–1.81)
Polymorphisms in the AGT gene (A-6G, A-20C, and G-217A) are significantly associated with an increased risk of essential hypertension in the Chinese population.
Supports AGT genotyping for hypertension risk assessment in Chinese patients; leaves open clinical utility and need for prospective trials.
OBJECTIVE: Although the angiotensinogen (AGT) gene has been implicated in the pathogenesis of essential hypertension, the results have been inconsistent. In this study, we performed a meta-analysis to assess the association of A-6G, A-20C and G-217A polymorphisms in the AGT gene with essential hypertension in the Chinese population. METHODS: Published literature from PubMed, Embase, China National Knowledge Infrastructure, China Biological Medicine and Wanfang Data was retrieved. Pooled odds ratio (OR) with 95% confidence interval (CI) was calculated using fixed- or random-effects models. RESULTS: Sixteen studies (4223 cases and 3743 controls) for A-6G polymorphism, ten studies (3116 cases and 2678 controls) for A-20C polymorphism and five studies (1268 cases and 1081 controls) for G-217A polymorphism were identified. The results from the meta-analyses indicated significant association of all three polymorphism with the risk of essential hypertension in the Chinese population (A-6G polymorphism: GG vs AA: OR = 1.45, 95% CI 1.17-1.81; A-20C polymorphism: CC vs AA: OR = 1.52, 95% CI 1.10-2.08; G-217A polymorphism: AA vs GG: OR = 2.36, 95% CI 1.44-3.89). CONCLUSIONS: Our study indicated that three polymorphisms (A-6G, A-20C and G-217A) in the AGT gene are associated with essential hypertension in the Chinese population.
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Xi et al. (2011) conducted a meta-analysis in essential hypertension. AGT gene polymorphisms (A-6G, A-20C, G-217A) vs. Reference genotypes (AA for A-6G, AA for A-20C, GG for G-217A) was evaluated on essential hypertension (OR 1.45, 95% CI 1.17-1.81). AGT gene polymorphisms A-6G (OR 1.45), A-20C (OR 1.52), and G-217A (OR 2.36) were significantly associated with an increased risk of essential hypertension in the Chinese population.
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