Lack of association of A-6G polymorphism of AGT gene with essential hypertension in the Chinese population

BACKGROUND: The angiotensinogen (AGT) A-6G gene polymorphism has been indicated to be related to the susceptibility of essential hypertension. However, the results are still unclear. OBJECTIVE AND METHODS: To survey the relationship between AGT A-6G gene polymorphism and essential hypertension, 18 separate studies with 9306 patients were analyzed through meta-analysis. The random-effect model was used to calculate the pooled odds ratio (OR) and its corresponding 95% confidence interval (CI). RESULTS: In this AGT A-6G gene polymorphism and essential hypertension meta-analysis of the Chinese population, the distribution of the G-allele frequency was 0.23 for the essential hypertension group and 0.21 for the control group. The association between the AGT A-6G gene polymorphism and essential hypertension in the entire sample population was not significant. The pooled OR for the frequency of the G allele was 1.10 (95% CI 0.96 to 1.27, Pheterogeneity < 0.00001, P = 0.17). In the stratified analysis by ethnicity, a significant association in Li and Mongolian ethnicities (P ≤ 0.05) was achieved. However, no significant association was found in other ethnicities such as Han, Tibetan, Kazakh, Bai and Yi (P > 0.05). CONCLUSIONS: The current meta-analysis suggested that AGT A-6G gene polymorphism might not be related to the increased risk of essential hypertension in the entire Chinese population. However, the G-allele of AGT A-6G might predispose to essential hypertension in the Li and Mongolian ethnicities.