Key result
Gastrointestinal extracellular slow waves persisted after contractions were abolished by nifedipine, with unchanged amplitude and velocity (P>0.10) but reduced frequency (24% lower; P=0.03).
Population
Porcine jejunum model (in vivo) and biophysical model
Comparison
Intra-arterial nifedipine administration and… vs Before nifedipine administration; conventional…
Design
Preclinical
Authors
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Supports bioelectrical origin of GI slow waves in animals; human validation without motion suppression remains needed.
p-value: p=>0.10
Gastrointestinal extracellular slow wave recordings are of bioelectrical origin and cannot be explained by motion artifacts, validating their use without routine motion suppression.
Angeli et al. (2013) studied Gastrointestinal extracellular slow wave recordings. Intra-arterial nifedipine administration vs. Before nifedipine administration was evaluated on Extracellular slow wave amplitude, downstroke rate, velocity, and downstroke width (p=>0.10). Gastrointestinal extracellular slow waves persisted after contractions were abolished by nifedipine, with unchanged amplitude and velocity (P>0.10) but reduced frequency (24% lower; P=0.03).
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