Correlation between CK-MB, TSH, LDL, HDL, Troponin T, Troponin I and myocardial infarction

Introduction: The assessment of patients with acute chest pain of possible cardiac cause continues to be a challenge and positive diagnosis has psychological, social and legal implications. The presence of ST segment elevation in the ECG is highly specific (but only about 50% sensitive) for acute myocardial infarction (MI). However, many patients presenting to coronary care units has chest pain without ST elevation in the ECG. The diagnostic possibilities in these cases include: acute coronary syndrome in evolution, or ‘non-ischaemic’ chest pain. The World Health Organization defines for diagnosing AMI, the presence of two of the three enlisted features namely, symptoms of myocardial ischemia, elevated levels of cardiac marker (protein or enzyme) concentrations in the blood, and a typical electrocardiographic pattern involving the development of Q waves or persistent T wave changes. Methods: In this Prospective study, the data of the registry maintained in the Department of biochemistry, Tertiary care Teaching Hospital were analysed. The WHO case definition was used to assign a diagnosis in 430 patients presenting to the emergency department with symptoms of cardiac ischemia.