Key result
In a study of 252 patients, plasma levels of NT-proBNP, GDF-15, and hs-cTnT did not significantly improve the predictive ability of traditional risk factors for the presence and extent of CAD.
Why the study?
To evaluate the association between plasma levels of GDF-15, hs-cTnT, and NT-proBNP and the presence of CAD in stable patients referred for elective coronary angiography.
Do plasma levels of GDF-15, hs-cTnT, and NT-proBNP predict the presence and extent of coronary artery disease in stable patients referred for elective coronary angiography?
Observational (n=252)
Do plasma levels of GDF-15, hs-cTnT, and NT-proBNP predict the presence and extent of coronary artery disease in stable patients referred for elective coronary angiography?
Plasma levels of NT-proBNP, GDF-15, and hs-cTnT do not provide incremental predictive value over traditional risk factors for diagnosing CAD in stable patients undergoing elective angiography.
These biomarkers add no incremental CAD prediction in stable elective patients; leaves open value in other settings or longitudinal outcomes.
Aim: This study investigated the association between plasma levels of GDF-15, hs-cTnT and NT-proBNP and the presence of coronary artery disease (CAD) in stable patients referred for elective coronary angiography. Methods: The outcome of CAD was defined as an ordinal variable with 3 levels. The association between each biomarker and the outcome was tested using the Winell and Lindbäck method. Results: In unadjusted analysis of 252 patients, GDF-15 and hs-cTnT were associated with the presence and extent of CAD. In multivariate regression analysis including traditional risk factors, this association was no longer significant. Conclusion: NT-proBNP, GDF-15 and hs-cTnT plasma levels do not seem to improve the predictive ability of traditional risk factors for CAD in stable patients referred for coronary angiography.
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Souaid et al. (2022) conducted an observational in Coronary artery disease (n=252). GDF-15, hs-cTnT and NT-proBNP vs. Traditional risk factors was evaluated on Presence and extent of CAD. In a study of 252 patients, plasma levels of NT-proBNP, GDF-15, and hs-cTnT did not significantly improve the predictive ability of traditional risk factors for the presence and extent of CAD.
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