Key result
Microvenous grafts placed in a microarterial system demonstrated progressive media fibroplasia, with a significant increase in media width from 17 μm at 1 week to 462 μm at 12 weeks (P<0.01).
Why the study?
Does interposing a vein graft into an arterial system cause progressive media fibroplasia in a rat model?
Does interposing a vein graft into an arterial system cause progressive media fibroplasia in a rat model?
Microvenous grafts placed in a microarterial system undergo progressive media fibroplasia, with media width increasing significantly over 12 weeks.
Answers are grounded in this paper and cite their sources.
Caution against clinical extrapolation from rat microvenous grafts; extends prior qualitative observations but leaves translational relevance open.
The sequential histopathologic changes in microvenous grafts placed in a microarterial system were studied. In 48 Sprague Dawley rats, a 1 cm segment of epigastric vein was interposed into a defect created in the femoral artery. Grafts were explored at 1, 2, 4, and 12 weeks. After an initial smooth muscle hyperplasia, a progressive fibroplasia of the media was observed. Only small focal areas of intimal hyperplasia were seen. The width of the media was measured with an eyepiece micrometer. A statistically significant ( P < 0.01) increase in width from 17 μm at 1 week to 462 μm at 12 weeks was noted. Although this process has been described before, this is the first quantitative assessment.
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McDonald et al. (1993) studied Microvenous grafts in microarterial system (n=48). Microvenous graft (epigastric vein interposed into femoral artery) was evaluated on Width of the media (p=<0.01). Microvenous grafts placed in a microarterial system demonstrated progressive media fibroplasia, with a significant increase in media width from 17 μm at 1 week to 462 μm at 12 weeks (P<0.01).
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