Key result
Vein grafts exposed to low shear stress developed enhanced intimal thickening (231 vs 36 μm), whereas high-shear grafts adapted via outward remodeling with increased lumen diameter (3.0 vs 3.7 mm).
Population
56 rabbits
Comparison
Vein graft with fistula placement, complete… vs Contralateral graft (high vs. low shear stress)
Design
Preclinical
Follow-up
1-28 days
Authors
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Rabbit model links shear stress to graft remodeling; leaves open translation to human CABG outcomes.
A novel rabbit model of vein graft arterialization demonstrates that low shear stress drives intimal thickening while high shear stress promotes outward remodeling.
Jiang et al. (2004) studied Vein bypass graft failure (n=56). Low shear stress environment (via partial distal branch ligation) vs. High shear stress environment (contralateral graft) was evaluated on Intimal thickening and lumen diameter. Vein grafts exposed to low shear stress developed enhanced intimal thickening (231 vs 36 μm), whereas high-shear grafts adapted via outward remodeling with increased lumen diameter (3.0 vs 3.7 mm).
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