Key result
This review summarizes in vivo animal models of vein graft disease, detailing the pathology of graft thrombosis, neointimal hyperplasia, atherosclerosis, and therapeutic prevention strategies.
This article provides a comprehensive review of in vivo animal models used to study vein graft disease and evaluates therapeutic strategies to prevent it.
Animal models consolidate vein graft pathology insights; leaves open translation of prevention strategies to clinical CABG practice.
Despite the very important use of arterial bypass conduits, vein grafts remain one cornerstone in coronary surgery. Newer studies show a saphenous vein graft patency of about 60% at 10 years postoperatively. This article reviews the in vivo (animal) models of vein graft disease. According to the different models, the findings on pathology of graft thrombosis, neointimal hyperplasia, and vein graft atherosclerosis are summarized. Therapeutic strategies to prevent vein graft disease (including external stenting, pharmacotherapy, and gene therapy) are reviewed.
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Schachner et al. (2006) conducted a review in Vein graft disease. In vivo (animal) models was evaluated. This review summarizes in vivo animal models of vein graft disease, detailing the pathology of graft thrombosis, neointimal hyperplasia, atherosclerosis, and therapeutic prevention strategies.
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