Key result
This systematic review evaluated published studies utilizing large animal models of vein graft disease, focusing on model types and therapeutic interventions such as external stents or mesh.
Why the study?
Intimal hyperplasia limits long-term saphenous vein graft patency after CABG, making large animal research models essential for understanding pathophysiology and evaluating therapeutic interventions.
Do therapeutic interventions like external stents/mesh prevent intimal hyperplasia in large animal models of vein graft disease?
Systematic Review
Do therapeutic interventions like external stents/mesh prevent intimal hyperplasia in large animal models of vein graft disease?
This systematic review summarizes the use of large animal models to study vein graft intimal hyperplasia and therapeutic interventions like external stents.
May guide large animal model selection for vein graft interventions; leaves open human translation.
Coronary artery bypass grafting remains the treatment of choice for a large cohort of patients with significant coronary disease. Despite the increased use of arterial grafts, the long saphenous vein remains the most commonly used conduit. Long-term graft patency continues to be the Achilles heel of saphenous vein grafts. This is due to the development of intimal hyperplasia, a chronic inflammatory disease that results in the narrowing and occlusion of a significant number of vein grafts. Research models for intimal hyperplasia are essential for a better understanding of pathophysiological processes of this condition. Large animal models resemble human anatomical structures and have been used as a surrogate to study disease development and prevention over the years. In this paper, we systematically review all published studies that utilized large animal models of vein graft disease with a focus on the type of model and any therapeutic intervention, specifically the use of external stents/mesh.
No takes yet. Share an insight, caveat, or question.
Fashina et al. (2022) conducted a systematic review in Vein graft intimal hyperplasia. External stents/mesh was evaluated. This systematic review evaluated published studies utilizing large animal models of vein graft disease, focusing on model types and therapeutic interventions such as external stents or mesh.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: