Key result
Experimental vein graft models often lack clinical relevance and target incorrect pathways, making selection critical.
Careful selection of experimental vein graft models is critical to ensure relevance to clinical coronary artery bypass grafting complications.
Requires rigorous validation of vein graft models against clinical endpoints; leaves open optimal designs for CABG research.
Experimental models of vein grafting need to have specific relevance to the clinical complications encountered in coronary artery bypass grafting: acute thrombosis, neointimaassociated stenosis, and progression of late-forming atherosclerotic lesions. Despite extensive use, many of these experimental models lack endpoint measures with clear analogies to their clinical counterparts and may in fact target the wrong (patho) physiologic process. Model selection is critical to further progress toward preventing these all too prevalent complications used for heart revascularization.
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Brian C. Cooley (2015) conducted a review in Coronary artery bypass grafting complications. Experimental models of vein grafting was evaluated. Experimental models of vein grafting often lack endpoint measures with clear clinical analogies and may target the wrong pathophysiologic processes, making careful model selection critical.
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