Key result
Activated inflammatory cells and cytokines in acute coronary syndromes may cause plaque fissure, increase platelet sensitivity, and turn the endothelium procoagulant and vasoconstrictor.
Design
Review
Authors
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Supports further investigation of inflammation in ACS; leaves open therapeutic targeting pending randomized trials.
Inflammation may play a crucial pathogenetic and prognostic role in acute coronary syndromes by increasing platelet sensitivity, altering endothelial properties, and causing plaque fissure.
Crea et al. (1995) conducted a review in Acute Coronary Syndromes. Activated inflammatory cells and cytokines in acute coronary syndromes may cause plaque fissure, increase platelet sensitivity, and turn the endothelium procoagulant and vasoconstrictor.
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