Key result
Coronary thrombosis from atherosclerotic plaque rupture directly causes acute MI and subsequent ischemic alterations.
Design
Review
Authors
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Anchors AMI reperfusion protocols; confirms core mechanisms while leaving open targeted prevention research.
This review outlines the pathophysiological cascade of acute myocardial infarction, highlighting plaque rupture, thrombosis, and the resulting cellular ischemic changes.
Joseph S. Alpert (2008) conducted a review in Acute Myocardial Infarction. Coronary arterial thrombosis caused by atherosclerotic plaque rupture is the direct cause of acute myocardial infarction, leading to reversible or irreversible ischemic myocardial alterations.
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