Key result
A dynamic interaction among damaged intima, platelet aggregates, and coronary spasm is postulated to occur as a prelude to thrombosis in acute transmural myocardial infarction.
Design
Review
Authors
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Early postulate on MI prelude remains hypothesis-generating; leaves open validation of intima-platelet-spasm dynamics in trials.
This historical review integrates clinical observations of platelet aggregation and coronary spasm with the discovery of thromboxane A2 and prostacyclin to explain the pathophysiology of acute myocardial infarction.
Philip B. Oliva (1981) conducted a review in Acute Myocardial Infarction. A dynamic interaction among damaged intima, platelet aggregates, and coronary spasm is postulated to occur as a prelude to thrombosis in acute transmural myocardial infarction.
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