Key result
Ganglionated plexus ablation emerges as a successful treatment for vasovagal syncope in young adults.
Why the study?
Vasovagal syncope causes significant burden without proven pharmacological prevention, prompting a review of the physiological aspects and clinical effectiveness of ganglionated plexus ablation.
Does ganglionated plexus ablation prevent vasovagal syncope in patients with vasovagal syncope?
Does ganglionated plexus ablation prevent vasovagal syncope in patients with vasovagal syncope?
Ganglionated plexus ablation is a rapidly emerging and potentially successful therapeutic option for treating vasovagal syncope, particularly in young adults.
Hypothesis-generating for ganglionated plexus ablation in vasovagal syncope; randomized trials needed before clinical adoption.
Vasovagal syncope (VVS) refers to a heterogeneous group of conditions whereby the cardiovascular reflexes normally controlling the circulation are interrupted irregularly in response to a trigger, resulting in vasodilation, bradycardia, or both. VVS affects one-third of the population at least once in their lifetime or by the age of 60, reduces the quality of life, and may cause disability affecting certain routines. It poses a considerable economic burden on society, and, despite its prevalence, there is currently no proven pharmacological treatment for preventing VVS. The novel procedure of ganglionated plexus (GP) ablation has emerged rapidly in the past two decades, and has been proven successful in treating syncope. Several parameters influence the success rate of GP ablation, including specific ablation sites, localization and surgical techniques, method of access, and the integration of other interventions. This review aims to provide an overview of the existing literature on the physiological aspects and clinical effectiveness of GP ablation in the treatment of VVS. Specifically, we explore the association between GPs and VVS and examine the impact of GP ablation procedures as reported in human clinical trials. Our objective is to shed light on the therapeutic significance of GP ablation in eliminating VVS and restoring normal sinus rhythm, particularly among young adults affected by this condition.
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Yarkoni et al. (2023) conducted a review in Vasovagal syncope (VVS). Ganglionated plexus (GP) ablation was evaluated. Ganglionated plexus ablation is reviewed as an emerging and successful procedure for treating vasovagal syncope and restoring normal sinus rhythm, particularly among young adults.
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