What is the clinical evidence from this study?

Study design: Cross-Sectional. Population: Obesity and Type 2 Diabetes (n=39). Intervention: Obesity and Type 2 Diabetes (Exposure) vs. Healthy controls. Primary outcome: Radial relative velocity ratio (VrE'/VrA') (p=<0.001).

What does this research mean for the field?

Obesity and type 2 diabetes are associated with significantly altered left atrial function detectable by MRI strain analysis prior to echocardiographic changes, and this dysfunction correlates with BMI and epicardial fat volume. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

December 1, 2016Cardiovascular DiabetologyOpen Access

Impact of obesity and epicardial fat on early left atrial dysfunction assessed by cardiac MRI strain analysis

Q: What are the key findings of this study?

Obesity and type 2 diabetes were associated with significantly altered left atrial function, including a 38.2% reduction in the radial relative velocity ratio (VrE'/VrA') compared to healthy controls.

Q: What does this research mean for the field?

Obesity and type 2 diabetes are associated with significantly altered left atrial function detectable by MRI strain analysis prior to echocardiographic changes, and this dysfunction correlates with BMI and epicardial fat volume. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

View Full Paper

Ask AI

Bookmark

Key result

Obesity and type 2 diabetes were associated with significantly altered left atrial function, including a 38.2% reduction in the radial relative velocity ratio (VrE'/VrA') compared to healthy controls.

Why the study?

Does cardiac MRI strain analysis detect early left atrial diastolic dysfunction and correlate with epicardial fat in patients with obesity and type 2 diabetes compared to healthy controls?

Population

39 adults, comprising 20 patients with obesity and type 2 diabetes and 19 healthy controls. Recruited at a…

Comparison

Cardiac magnetic resonance imaging with feature… vs Healthy controls with no history of cardiac…

Design

Case-control, Epicardial fat was quantified blindly between patients and…

Authors

MEMorgane EvinUniversité Gustave Eiffel KBKathryn M. BroadhouseUniversity of the Sunshine Coast FCFraser M. CallaghanUniversity Children's Hospital Zurich

Discussion

Member takes

Implication

MRI strain may detect subclinical LA dysfunction in obesity/T2D; hypothesis-generating for epicardial fat links.

Study Design

Type

Cross-Sectional (n=39)

Multicenter

Structured PICO

Does cardiac MRI strain analysis detect early left atrial diastolic dysfunction and correlate with epicardial fat in patients with obesity and type 2 diabetes compared to healthy controls?

Population

39 adults, comprising 20 patients with obesity and type 2 diabetes (mean age 54.6 ± 7.8 years, 40% female, BMI >30 kg/m2) and 19 healthy controls (mean age 47.5 ± 12.5 years, 45% female, BMI <30 kg/m2). Recruited at a single center in Australia.

Intervention

Cardiac magnetic resonance imaging (CMR) with feature tracking for left atrial strain analysis and 2-point Dixon for epicardial fat quantification

Comparator

Healthy controls with no history of cardiac disease

Outcome

Left atrial function (phasic longitudinal strain, strain rates, radial motion fraction, and radial velocities) to detect early diastolic dysfunctionsurrogate

Main Result

Absolute Event Rate: 0.7% vs 1.2%

p-value: p=<0.001

Cardiac MRI strain analysis can detect early subclinical left atrial diastolic dysfunction in patients with obesity and type 2 diabetes, which correlates strongly with epicardial adiposity.

Limitations

Relatively small sample size
Slight age range difference between patients and healthy volunteers
Uniform diagnosis of obesity and diabetes did not permit deconvolution of the contributions of these conditions
Clinical evaluation of the control subjects was limited and measured blood pressures were not available
relatively small sample size
slightly age range difference between patients and healthy volunteers
uniform diagnosis of obesity and diabetes, which did not permit deconvolution of the contributions
limited clinical evaluation of control subjects (no blood pressures)
lack of control echocardiographic data

Cite This Study

Evin et al. (2016) conducted a cross-sectional in Obesity and Type 2 Diabetes (n=39). Obesity and Type 2 Diabetes (Exposure) vs. Healthy controls was evaluated on Radial relative velocity ratio (VrE'/VrA') (p=<0.001). Obesity and type 2 diabetes were associated with significantly altered left atrial function, including a 38.2% reduction in the radial relative velocity ratio (VrE'/VrA') compared to healthy controls.

synapsesocial.com/papers/6a15ea3dbdb7c25666523aaa https://doi.org/10.1186/s12933-016-0481-7

Topics

Cardiac MRI

View Full Paper

Ask AI

Bookmark

Impact of obesity and epicardial fat on early left atrial dysfunction assessed by cardiac MRI strain analysis

Discussion

Member takes

Implication

Study Design

Structured PICO

Main Result

Limitations

Cite This Study

Topics

Impact of obesity and epicardial fat on early left atrial dysfunction assessed by cardiac MRI strain analysis

Discussion

Member takes

Implication

Study Design

Structured PICO

Main Result

Limitations

Cite This Study

Also Consider

Topics

Also Consider