Key result
The X447 allele of the LPL gene was associated with higher systolic blood pressure and pulse pressure (P<0.05) in hypertensive patients with dyslipidemia compared to the S447S genotype.
Why the study?
Is the S447X polymorphism of the LPL gene associated with lipoprotein lipid and blood pressure levels in Chinese patients with essential hypertension?
Population
904 Chinese subjects with essential hypertension, not treated with antihypertensive medications for at least…
Comparison
X447 allele of the LPL gene (S447X polymorphism) vs S447S genotype
Design
Cross-sectional
Authors
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Should not yet change hypertension management; leaves open causal role of LPL S447X in blood pressure.
Cross-Sectional (n=904)
Is the S447X polymorphism of the LPL gene associated with lipoprotein lipid and blood pressure levels in Chinese patients with essential hypertension?
p-value: p=<0.05
The LPL S447X polymorphism is associated with favorable lipid profiles but higher systolic and pulse pressure in dyslipidemic Chinese patients with essential hypertension.
Liu et al. (2004) conducted a cross-sectional in Essential hypertension (n=904). X447 allele of the LPL gene vs. S447S genotype was evaluated on Lipoprotein lipid and blood pressure levels (p=<0.05). The X447 allele of the LPL gene was associated with higher systolic blood pressure and pulse pressure (P<0.05) in hypertensive patients with dyslipidemia compared to the S447S genotype.
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