Key result
Resting heart rate was significantly associated with plasma NT-proBNP levels (partial correlation coefficient 0.82; 95% CI 0.18-1.51; P=0.011), with the association strengthened in subjects over 60.
Why the study?
Is high resting heart rate associated with elevated plasma NT-proBNP levels in a community-based population?
Cross-Sectional (n=1,567)
No
Is high resting heart rate associated with elevated plasma NT-proBNP levels in a community-based population?
Effect estimate: partial correlation coefficient 0.82 (95% CI 0.18-1.51)
p-value: p=0.011
Resting heart rate is positively associated with plasma NT-proBNP levels in elderly individuals, suggesting a link between resting heart rate and subclinical cardiac dysfunction.
BACKGROUND: N-terminal pro-brain natriuretic peptide (NT-proBNP) is associated with an increased risk of cardiac insufficiency, which possibly leads to heart failure. However, the relationship between resting heart rate and NT-proBNP is unclear. OBJECTIVE: This study focuses on this relativity between resting heart rate and plasma NT-proBNP levels in a surveyed community-based population. METHODS: We evaluated the relativity between resting heart rate and plasma levels of NT-proBNP in 1,567 participants (mean age 61.0 years, range 21-96 years) from a community-based population in Beijing, People's Republic of China. RESULTS: In patients with high resting heart rate (≥75 beats/min), NT-proBNP was higher than in those having low resting heart rate (<75 beats/min). In multiple linear stepwise regression analysis, plasma NT-proBNP was associated with resting heart rate (partial correlation coefficient, 0.82; 95% confidence interval, 0.18-1.51; P=0.011). A subsequent subgroup analysis revealed that the association between resting heart rate and plasma NT-proBNP was strengthened in subjects over 60 years old (partial correlation coefficient 1.28; 95% confidence interval, 0.49-2.36; P=0.031); while the relativity between resting heart rate and plasma NT-proBNP was not emerged in the younger subgroup (<60 years old). CONCLUSIONS: Resting heart rate was associated with plasma NT-proBNP in the elderly, which indicated a relationship between resting heart rate and cardiac function damage.
No takes yet. Share an insight, caveat, or question.
Ye et al. (2014) conducted a cross-sectional in Community-based population (n=1,567). Resting heart rate ≥75 beats/min vs. Resting heart rate <75 beats/min was evaluated on Plasma NT-proBNP levels (partial correlation coefficient 0.82, 95% CI 0.18-1.51, p=0.011). Resting heart rate was significantly associated with plasma NT-proBNP levels (partial correlation coefficient 0.82; 95% CI 0.18-1.51; P=0.011), with the association strengthened in subjects over 60.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: