Key result
Cold blood cardioplegia resulted in significantly lower postoperative troponin I release at 1, 24, and 48 hours compared to warm blood cardioplegia (P<0.05) during aortic valve surgery.
Why the study?
Does intermittent antegrade cold blood cardioplegia reduce myocardial injury compared to warm blood cardioplegia in patients with left ventricular hypertrophy undergoing aortic valve surgery?
Population
35 patients with left ventricular hypertrophy and aortic stenosis undergoing aortic valve replacement surgery
Comparison
Intermittent antegrade cold blood cardioplegia vs Intermittent antegrade warm blood cardioplegia
Design
RCT, prospectively randomised
Follow-up
48 hours postoperatively
Authors
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Supports cold blood cardioplegia to limit injury in LVH patients during AVR; extends CABG myocardial protection data to valve surgery.
RCT (n=35)
prospectively randomised
Does intermittent antegrade cold blood cardioplegia reduce myocardial injury compared to warm blood cardioplegia in patients with left ventricular hypertrophy undergoing aortic valve surgery?
p-value: p=<0.05
Cold blood cardioplegia is associated with less ischemic stress and myocardial injury than warm blood cardioplegia in patients with hypertrophic hearts undergoing aortic valve surgery, though both techniques offer sub-optimal protection.
Raimondo Ascione (2002) conducted an RCT in aortic stenosis with left ventricular hypertrophy (n=35). intermittent antegrade cold blood cardioplegia vs. intermittent antegrade warm blood cardioplegia was evaluated on Postoperative myocardial troponin I release (p=<0.05). Cold blood cardioplegia resulted in significantly lower postoperative troponin I release at 1, 24, and 48 hours compared to warm blood cardioplegia (P<0.05) during aortic valve surgery.