What question did this study set out to answer?

To assess the risk of peptic ulcer perforation or hemorrhage associated with nonsteroidal antiinflammatory drug (NSAID) therapy as a class and across individual agents.

January 1, 1993Arthritis & Rheumatism

Variation in the risk of peptic ulcer complications with nonsteroidal antiinflammatory drug therapy

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Authors

RSRuth SavageUniversity of Otago PMPeter MöllerSahlgrenska University Hospital CBC. L. BallantyneChristchurch Hospital

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Implication

Case-control study finds varying risks of peptic ulcer perforation and hemorrhage across NSAID therapies, indicating individual drug choices influence complication severity.

Key Points

To assess the risk of peptic ulcer perforation or hemorrhage associated with nonsteroidal antiinflammatory drug (NSAID) therapy as a class and across individual agents.
Conducted a case-control study analyzing medication histories in 494 patients with peptic ulcer complications and 972 matched control subjects.
NSAID therapy was associated with an overall unadjusted odds ratio of 5.1 and an adjusted odds ratio of 4.1 for peptic ulcer complications compared to controls.
Piroxicam carried an unadjusted odds ratio of 6.3 (95% CI 3.3–12.0) and an adjusted odds ratio of 6.4 (95% CI 2.8–15.0).
Combined use of diclofenac, ketoprofen, and sulindac exhibited an unadjusted odds ratio of 2.9 (95% CI 2.0–4.2) and an adjusted odds ratio of 3.3 (95% CI 2.0–5.5).

Cite This Study

Savage et al. (1993) studied this question.

synapsesocial.com/papers/6a15fb0ccaf7e3ea0ee3eea0 https://doi.org/10.1002/art.1780360114

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Implication

Case-control study finds varying risks of peptic ulcer perforation and hemorrhage across NSAID therapies, indicating individual drug choices influence complication severity.

Variation in the risk of peptic ulcer complications with nonsteroidal antiinflammatory drug therapy

Discussion

Member takes

Implication

Key Points

Cite This Study

Variation in the risk of peptic ulcer complications with nonsteroidal antiinflammatory drug therapy

Discussion

Member takes

Implication

Key Points

Cite This Study

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