Key result
Proton pump inhibitors (RR 0.33; 95% CI 0.27-0.39), H2-receptor antagonists, and nitrates were associated with reduced risk of upper gastrointestinal bleeding in patients taking NSAIDs or aspirin.
Why the study?
Do antisecretory drugs and nitrates reduce the risk of upper gastrointestinal peptic ulcer bleeding in patients taking NSAIDs, antiplatelet agents, or anticoagulants?
Population
8,309 patients
Comparison
Antisecretory drugs or nitrates vs Non-use of antisecretory drugs or nitrates
Design
Case-control
Authors
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Supports PPI gastroprotection in NSAID users; leaves open causal confirmation and extension to anticoagulants.
Case-Control (n=8,309)
Do antisecretory drugs and nitrates reduce the risk of upper gastrointestinal peptic ulcer bleeding in patients taking NSAIDs, antiplatelet agents, or anticoagulants?
Relative Risk: 0.33 (95% CI 0.27–0.39)
Proton pump inhibitors, H2-receptor antagonists, and nitrates are associated with a reduced risk of upper gastrointestinal bleeding in patients taking NSAIDs or aspirin, with PPIs showing the most consistent protection across antiplatelet agents.
Lanas et al. (2007) conducted a case-control in Upper gastrointestinal peptic ulcer bleeding (UGIB) (n=8,309). Antisecretory drugs (PPIs, H2-RAs) and nitrates vs. Non-use was evaluated on Upper GI peptic ulcer bleeding (UGIB) (RR 0.33, 95% CI 0.27-0.39). Proton pump inhibitors (RR 0.33; 95% CI 0.27-0.39), H2-receptor antagonists, and nitrates were associated with reduced risk of upper gastrointestinal bleeding in patients taking NSAIDs or aspirin.
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