Cilnidipine treatment for 8 weeks significantly increased left-ventricular midwall fractional shortening in Chinese patients with hypertension (P<0.01), independently of blood pressure changes.
Does cilnidipine improve left-ventricular midwall fractional shortening in Chinese patients with mild to moderate essential hypertension?
Short-term therapy with cilnidipine improves left-ventricular midwall systolic function independently of blood pressure reduction in patients with mild to moderate hypertension.
p-value: p=<0.01
Despite normal indices of left-ventricular (LV) chamber function, patients with hypertension are thought to have depressed LV midwall systolic shortening. This study was designed to investigate effects of short-term therapy with cilnidipine on LV midwall fractional shortening (mFS) in Chinese patients with hypertension. Thirty-seven patients with mild to moderate essential hypertension underwent a 2 week placebo run-in period, then received 5-10 mg/day of cilnidipine orally for 8 weeks. At the end of the placebo period and treatment, patients were examined by echocardiogram, measuring and calculating LV ejection fraction (EF), LV endocardial fraction shortening (eFS), and LV mFS. Compared with the normotensive group, the hypertensive group had a significantly higher eFS (P 0.05); however, absolute mFS and corrected mFS were increased significantly (P 0.05). Midwall fractional shortening is more reliable and sensitive than conventional systolic function measures in assessment of systolic function; cilnidipine can improve left-ventricular systolic function (mFS) independently of blood pressure changes in Chinese patients who have hypertension.
Ma et al. (Mon,) conducted a other in Hypertension (n=37). Cilnidipine vs. Normotensive control group / Baseline was evaluated on Left-ventricular midwall fractional shortening (mFS) (p=<0.01). Cilnidipine treatment for 8 weeks significantly increased left-ventricular midwall fractional shortening in Chinese patients with hypertension (P<0.01), independently of blood pressure changes.