Key result
Cilnidipine significantly increased the heart-to-mediastinum ratio (P<0.05) and decreased the washout rate (P<0.02), suppressing cardiac sympathetic overactivity more than amlodipine.
Why the study?
Does cilnidipine improve cardiac sympathetic nervous system activity compared to amlodipine in patients with mild essential hypertension?
Population
47 patients with mild essential hypertension, and 12 normotensive subjects for comparison
Comparison
Cilnidipine 10 to 20 mg/d for 3 months vs Amlodipine 5 to 10 mg/d for 3 months
Design
Cohort
Follow-up
3 months
Authors
Loading...
May support cilnidipine for sympathetic modulation in hypertension; hypothesis-generating and leaves open outcome benefits.
Does cilnidipine improve cardiac sympathetic nervous system activity compared to amlodipine in patients with mild essential hypertension?
p-value: P<0.05
Cilnidipine, an N-type calcium channel antagonist, suppresses cardiac sympathetic overactivity in patients with essential hypertension more effectively than amlodipine.
Sakata et al. (1999) studied Essential hypertension (n=59). Cilnidipine vs. Amlodipine was evaluated on Heart-to-mediastinum (H/M) ratio and washout rate on MIBG cardiac imaging (p=P<0.05). Cilnidipine significantly increased the heart-to-mediastinum ratio (P<0.05) and decreased the washout rate (P<0.02), suppressing cardiac sympathetic overactivity more than amlodipine.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: