Key result
Hypertension significantly attenuated rapid cooling contracture magnitude in isolated rat left ventricular myocytes compared to normotensive controls across pacing frequencies of 0.2 to 1.0 Hz.
Hypertension alters cellular Ca2+ homeostasis in rat cardiocytes, leading to a mismatch between releasable SR Ca2+ content and sarcoplasmic volume.
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No immediate clinical implications; leaves open whether SR Ca2+ mismatch contributes to human hypertensive heart disease.
Stauffer et al. (1997) studied Hypertension. Hypertension (induced by abdominal aortic banding) vs. Normotensive control rats was evaluated on Rapid cooling contracture (RCC) magnitude. Hypertension significantly attenuated rapid cooling contracture magnitude in isolated rat left ventricular myocytes compared to normotensive controls across pacing frequencies of 0.2 to 1.0 Hz.
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