October 21, 1997Circulation
Electrophysiological Effects of Long, Linear Atrial Lesions Placed Under Intracardiac Ultrasound Guidance
Key result
Intracardiac echocardiography-guided radiofrequency ablation created transmural, continuous linear lesions with complete conduction block in 100% of the 6 pigs tested.
Why the study?
Does intracardiac echocardiography-guided radiofrequency ablation create transmural linear lesions with complete conduction block in the right atrium of normal pigs?
Population
Six normal pigs
Design
Preclinical
Follow-up
15 days
Authors
Discussion
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Member takes
Implication
Feasible in normal porcine right atrium; leaves open translation to human ablation procedures.
Key Points
- This research aims to assess the ability of radiofrequency energy to create effective conduction block through linear lesions in the heart's right atrium.
- Conducted in six pigs utilizing intracardiac echocardiography for catheter positioning.
- Applied radiofrequency energy sequentially across multiple coil electrodes to create three linear ablation lesions.
- Performed epicardial mapping post-ablation to analyze conduction patterns after a 15-day healing period.
- All lesions demonstrated complete conduction block across them with activation delays averaging 64±16 ms.
- Mean lesion lengths were 21±4 mm, with widths of 2.8±0.6 mm, precisely located within 0.3±0.5 mm of the targeted sites.
- Histological analysis confirmed transmural fibrosis for all lesions, indicating successful ablation.
Structured PICO
Does intracardiac echocardiography-guided radiofrequency ablation create transmural linear lesions with complete conduction block in the right atrium of normal pigs?
P
Population
Six normal pigs
I
Intervention
Linear ablative lesions created by radiofrequency energy applied sequentially to multiple coil array catheters guided by intracardiac echocardiography in three right atrial locations
O
Outcome
Conduction block across the lesions determined by epicardial mapping at 15 dayssurrogate
Intracardiac echocardiography can effectively guide the creation of transmural, continuous linear radiofrequency lesions that achieve complete conduction block in the right atrium of a porcine model.
Cite This Study
Olgin et al. (1997) studied Atrial fibrillation ablation (n=6). Intracardiac echocardiography-guided radiofrequency ablation was evaluated on Complete conduction block across the lesions. Intracardiac echocardiography-guided radiofrequency ablation created transmural, continuous linear lesions with complete conduction block in 100% of the 6 pigs tested.