Relationship of regional myocardial perfusion to segmental wall motion: a physiologic basis for understanding the presence and reversibility of asynergy.
Why the study?
Does regional myocardial perfusion correlate with segmental wall motion asynergy in patients with coronary artery disease?
Population
54 patients with coronary artery disease, including 27 without evidence of myocardial infarction.
Design
Cross-sectional
Authors
Discussion
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Implication
Regional perfusion defects associate with asynergy in CAD; hypothesis-generating for reversible ischemia from exercise defects, needing prospective confirmation.
Structured PICO
Does regional myocardial perfusion correlate with segmental wall motion asynergy in patients with coronary artery disease?
P
Population
54 patients with coronary artery disease (evaluating 270 segments), including 27 without evidence of myocardial infarction.
I
Intervention
Assessment of regional myocardial perfusion by thallium-201 scintigraphy and segmental wall motion by biplane contrast ventriculograms.
O
Outcome
Relationship between regional perfusion and segmental wall motion (asynergy).surrogate
Resting asynergy can occur in patients without prior infarction due to jeopardized perfusion, and exercise-induced perfusion abnormalities may indicate reversible resting ischemia.
Cite This Study
Massie et al. (1978) studied this question.